Health and Care Research Wales Palliative Care Portfolio Studies

Studies in Set Up

   

Open Studies

 

MENAC: A randomised, open-label trial of a Multimodal Intervention (Exercise, Nutrition and Anti-inflammatory Medication) plus standard care versus standard care alone to prevent / attenuate Cachexia in advanced cancer patients undergoing chemotherapy.

 Chief Investigator: Professor Ken Fearon, Dr Matthew Maddocks

 Co-Investigator: Dr Anthony Byrne

Sites in Wales: TBC.  Further details


 

Cariad: Caring for the dying at home: can lay carers safely give extra, as-needed, symptom control to their loved ones using injections under the skin?

Chief Investigator: Professor Clare Wilkinson

Co-Investigator: Dr Anthony Byrne

Sites in Wales: TBC.  Further details


 

HIDDEN: Hospice in-patient deep vein thrombosis detection study

Chief Investigator: Prof Miriam Johnson

Co-Investigator: Prof Simon Noble

Sites in Wales: TBC.  Further details

 

 

Optcare Neuro: Evaluation of the clinical and cost-effectiveness of Short-term Integrated Palliative Care Services (SIPC) to OPTimise CARE for people with advanced longterm Neurological conditions

Chief Investigator: Prof Irene Higginson

Sites in Wales: Velindre Cancer Centre, Llandough Hospital, PI: Dr Anthony Byrne. Further details 

 

 

ROCS: Palliative radiotherapy in addition to self expanding metal stent for improving outcomes of dysphagia and survival in advanced oesophageal cancer

Chief Investigator: Dr Anthony Byrne, Dr Douglas Adamson

Sites in Wales: Velindre Cancer Centre, PI: Dr Anthony Byrne; University Hospital of Wales, PI: Dr Anthony Byrne; Llandough Hospital' PI: Dr Anthony Byrne.  Further details 

 

Closed Studies

 

EAGLE: Improving the wellbeing of men by addressing the late effects of radical treatment for prostate cancer

Chief Investigator; Dr John Stafforth; Dr Annmarie Nelson

Sites in Wales: Velindre Cancer Centre, University Hospital of  Wales. Further details

 

 

TVT: An international, multicentre, open randomised parallel group trial comparing a two step approach for cancer pain relief with the standard three step approach of the WHO analgesic ladder in patients with cancer pain requiring step 2 analgesia

Chief Investigator: Prof Marie Fallon. Sites in Wales: Velindre Cancer Centre, PI: Dr Mark Taubert. Further details

 

 

SCORAD III: A randomised phase III trial of single fraction radiotherapy compared to multifraction radiotherapy in patients with metastatic spinal cord compression

Chief Investigator: Peter Hoskin. Sites in Wales: Velindre Cancer Centre, PI: Dr Jason Lester; Singleton Hospital, PI:Dr Kate Parker.

 

 

IPAC: Inflammatory biomarkers in prognosis an advanced cancer: A multicentre prospective observational study

Chief Investigator: Dr Barry Laird. Sites in Wales: Llandough Hospital, PI: Dr ANthony Byrne; University Hospital of Wales, PI: Dr Mel Jefferson. Further details

 

 

ALICAT: A feasibility study to inform the design of a randomised controlled trial to identify the most clinically and cost effective length of anticoagulation with low molecular weight heparin in the treatment of cancer associated thrombosis

Chief Investigator: Dr Simon Noble. Sites in Wales: Velindre Cancer Centre, PI: Prof Simon Noble; Rpyal Gwent Hospital, PI: Prof Simon Noble. Further details

 

 

AFTER: Service user feedback as a means of refining the iWantGreatCare questionnaire.

Chief Investigator: Dr Annmarie Nelson, MCPCRC. Sites in Wales: Hospice of the Valleys; Marie Curie Hospice, Cardiff & Vales. Further details.. 

 

 

Patient Experience of LIving with CANcer associated thrombosis. The PELICAN study

Chief Investigator: Dr Simon Noble. Sites in Wales: Royal Gwent Hospital, PI: Prof Simon Noble; Velindre Cancer Centre, PI: Prof Simon Noble. 

 

 

DESIGNER: Developing a simple screening tool to detect chronic gastrointestinal (GI) symptoms after pelvic radiotherapy in cancer survivors.

Chief Investigator: Dr John Green. Sites in Wales: Velindre Cancer Centre. PI: Dr John Green. Llandough Hospital, PI: Dr John Green. 

 

 

Canopy: A study of quality of care needs for patients with idiopathic pulmonary fibrosis, and their carers, across disease trajectory.

Chief Investigator: Dr Anthony Byrne, MCPCRC Cardiff. Sites in Wales: Llandough Hospital, PI: Dr Ben Hope-Gill; Morriston Hospital, PI: Dr Kim Harrison. Further details

 

 

RECC: The role of exercise in patients with cancer cachexia: a study of preferences, motivation and outcomes of importance in patients with cancer.

Chief Investigator: Dr Anthony Byrne, MCPCRC Cardiff. Sites in Wales: Velindre Cancer Centre, Dr Anthony Byrne; Llandough Hospital, Dr Anthony Byrne; Singleton Hospital, PI: Dr Rosie Stevens; Royal Gwent Hospital, PI:Dr Simon Noble; Nevill Hall Hospital, PI: Dr Mick Button. Further details

 

 

SOB_LC II: A randomised trial of high versus low intensity training in breathing techniques for breathlessness in patients with malignant lung disease: early intervention

Chief Investigator: Dr Miriam Johnson. Sites in Wales: Velindre Cancer Centre, Llandough Hospital, PI: Dr Anthony Byrne. Further details

 

 

PREGABALIN: Double-blind randomised controlled trial of pregabalin versus placebo in conjunction with palliative radiotherapy for malignant bone pain

Chief Investigator: Marie Fallon. Sites in Wales: Velindre Cancer Centre, Llandough Hospital, PI: Dr Anthony Byrne. 

 

 

Modafinil for the treatment of fatigue in lung cancer: a multicentre randomised, double-blinded, placebo controlled trial.

Chief Investigator: Dr Bee Wee. Sites in Wales: Llandough Hospital, PI: Dr Anthony Byrne; Withybush Hospital, PI: Dr Haq

 

 

Pathway to Portfolio Studies

Studies in Set Up

 

To be confirmed

 

Open Studies

 

The Thrombosis Registry of Hospice and Palliative Units (TROPHY): an online database to collect focussed clinical data about palliative care patients with VTE.

Chief Investigator: Dr Simon Noble, Royal Gwent Hospital, Newport; Co-investigators: Stephanie Sivell, Dr Annmarie Nelson, MCPCRC; Prof Kerry Hood, Mr John Evans, Mr Jose Miguel Cossio Narvaez, South East Wales Trials Unit; Professor Miriam Johnson, Dr Anthony Maraveyas, Hull York Medical School.

 

Closed Studies

 

PACT: Development of an intervention to support lung cancer Patients and their clinicians when considering systemic Anti-Cancer Therapy.

Chief Investigator: Dr Annmarie Nelson, MCPCRC; Co-investigators Dr Simon Noble, Dr Jason Lester, Dr Anthony Byrne, Dr Stephanie Sivell

 

Supporting people bereaved through advanced illness: A systematic review of the evidence and development of a core outcome set for bereavement research in palliative care.

Chief Investigator: Dr Emily Harrop

Sites in Wales: NA

 

TOPCAT: A Tenovus study OPtimising the patient journey with Cancer Associated Thrombosis

Chief Investigator:  Dr Simon Noble ; Co-investigators  Dr Annmarie Nelson, Hayley Prout, Dr Gareth Watts

 

 

TACT: what impact does Research Partner involvement have on the working practices of a cancer clinical trial and academic research centre?.

Chief Investigator: Dr Jim Fitzgibbon, MCPCRC; Co-investigators Dr Noreen Hopewell-Kelly, Dr Jessica Baillie, Natalie Simons, Prof Gareth Griffiths, Dr Annmarie Nelson

 

 

Caring for young adults with complex disabilities in adult specialist palliative care services: A national survey of the views of nursing staff.

Chief Investigator: Dr Megumi Baba, University Hospital of Wales; Co-investigators: Dr Annmarie Nelson, Dr Emily Harrop, MCPCRC.

 

 

An evaluation of nurse led palliative care clinics.

Chief Investigator: Dr Annmarie Nelson, MCPCRC; Co-investigators: Dr Anthony Byrne, Dr Emily Harrop, MCPCRC; Liz Hayles, Dr Herson, GP Practice Rumney.

 

 

Engaging black and minority ethnic communities for uptake of hospice services.

Chief Investigator: Dr Annmarie Nelson, MCPCRC; Co-investigator: Dr Emily Harrop, MCPCRC.

 

 

Carer Support: Managing home based care and the training needs of carers of advanced cancer patients.

Chief Investigator: Dr Annmarie Nelson, MCPCRC; Co-investigators: Dr Emily Harrop, Dr Anthony Byrne, MCPCRC

 

 

Enabling positive transition: identifying the training needs of Adult Specialist Palliative Care (SPC) Teams to care for young adults with life-limiting conditions including complex needs.

Chief Investigator: Dr Annmarie Nelson, MCPCRC; Co-investigators: Stephanie Sivell, MCPCRC; Dr Victoria Lidstone, University Hospital of Wales.

 

 

QualFRAG: A Qualitative study exploring patients’ experience on the FRAGMATIC lung cancer trial.

Chief Investigator: Dr Simon Noble, Royal Gwent Hospital, Newport

 

 

A QUALitative exploration of the experiences of the patients from the ZICE clinical trial (metastatic breast cancer) receiving intravenous or oral bisphosphonates at clinic or home.

Chief Investigator: Dr Annmarie Nelson, MCPCRC.

 

 

Validating breathlessness measures for use in patients with lung cancer: a cognitive interview study.

Chief Investigator: Dr Annmarie Nelson, MCPCRC.

 

 

National Portfolios

Do you want to know more about what is happening nationally?

Click on the links below for further information on the Welsh (Health and Care Research Wales) and UK wide (NIHR) Clinical Research Portfolios.

 

Health and Care Research Wales Clinical Research Portfolio

Registering your study on the HCRW Clinical Research Portfolio enables you to access HCRW CRC resources:

HCRW  Support and Delivery

HCRW Training Programme

Registration also gives your study priority access to NHS Support Costs and your study recruitment in NHS sites will contribute to the Health Board's Activity Based Funding allocations.

To find out more about HCRW Portfolio eligibility, click here.

 

NIHR Clinical Research Portfolio - includes the National Institute for Health Research Portfolio in England, and the corresponding portfolios of Northern Ireland, Scotland and Wales

NCRI Palliative Care Clinical Studies Group Portfolio Map - provides a visual representation of all palliative care studies that are approved for entry onto the NIHR Portfolio.